Inducing a tolerogenic microenvironment within tissues
نویسندگان
چکیده
منابع مشابه
Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment
We have proposed that tolerance can be maintained through the induction, by Treg cells, of a tolerogenic microenvironment within tolerated tissues that inhibits effector cell activity but which supports the generation of further Treg cells by "infectious tolerance." Two important components of this tolerogenic microenvironment depend on metabolism and nutrient sensing. The first is due to the u...
متن کاملTolerogenic Properties of Lymphatic Endothelial Cells Are Controlled by the Lymph Node Microenvironment
Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic endothelial cells in mice directly express peripheral tissue antigens, including tyrosinase, and induce deletion of specific CD8 T cells via Programmed Death Ligand-1 (PD-L1). Here, we demonstrate that high-level expression of peripheral ...
متن کاملGrowth of Listeria monocytogenes within a Caramel-Coated Apple Microenvironment
UNLABELLED A 2014 multistate listeriosis outbreak was linked to consumption of caramel-coated apples, an unexpected and previously unreported vehicle for Listeria monocytogenes. This outbreak was unanticipated because both the pH of apples (<4.0) and the water activity of the caramel coating (<0.80) are too low to support Listeria growth. In this study, Granny Smith apples were inoculated with ...
متن کاملLymphoid-like fibroblast reticular cells in the secondary lymphoid tissues and tumor microenvironment induce immunosuppression via maintaining the tolerogenic function of myeloid populations
Recently, compelling evidence reveals that stromal populations, especially the fibroblastic reticular cells (FRC), of the secondary lymphoid organs (SLO) not only serve as structure scaffold for organizing and maintaining the structure of the lymphoid tissues, but also possess crucial functions in immune regulation, including induction of T cell tolerance and the generation of regulator T cells...
متن کاملCervical (pre)neoplastic microenvironment promotes the emergence of tolerogenic dendritic cells via RANKL secretion
The progression of genital human papillomavirus (HPV) infections into preneoplastic lesions suggests that infected/malignant cells are not adequately recognized by the immune system. In this study, we demonstrated that cervical/vulvar cancer cells secrete factor(s) that affect both the maturation and function of dendritic cells (DC) leading to a tolerogenic profile. Indeed, DC cocultured with c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2011
ISSN: 1478-6354
DOI: 10.1186/ar3406